Life  Sciences Case Study featuring Syngenta

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Life Sciences

Syngenta uses OpenViz to provide the visualization front-end for its in vitro High-Throughput Screening (HTS) software tool set.

Syngenta, a world-leading supplier of crop solutions based on chemical and biotechnology products designed to improve crop yield and food quality, has created a suite of applications to help scientists understand HTS data. HTS, used in agribusiness and pharmaceutics, allows the rapid evaluation of candidate molecules and combinations to find those suited for specific uses. OpenViz can present the resulting data as interactive charts and graphs, helping Syngenta scientists more easily understand and analyze HTS data to find the best-suited molecules.

“We test hundreds of thousands of molecules annually in an ever-increasing number of different biochemical and cell-based assays,” said Dr. David Youle, Head of Screening and Logistics at Syngenta. “OpenViz allows us to increase the understanding of interactions between research compounds and their precise molecular targets, and identify more quickly which compounds are of interest.”

“We were familiar with a number of products that could provide many of the features we needed, but which lacked flexibility or simplicity,” explained Graham Mullier, Chemoinformatics Team Leader at Syngenta. “We wanted a modular, component-based system that would make it easier for us to build something quickly and to match the process that the scientists were using. By using OpenViz components to build some small, focused visualization applications, we have been able to produce a tool that suits our users very well.”

Syngenta conducts breakpoint analysis to produce a measure of potency and quality for each sample. Researchers can assign different variables to the x-, y- and z-axes and the range of each data variable can be cropped to focus on a specific region of the data space.

Sample dose-response curve plot.

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